DONALDSON, JOSHUA MICHAEL,HORNE, DAVID A.,MA, YUELONG,ZER, CINDY,BZYMEK, KRZYSZTOF,AVERY, KENDRA NICOLE,WILLIAMS, JOHN C.
申请号：
CA2814040
公开号：
CA2814040A1
申请日:
2011.10.10
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
An antibody framework binding interface for the cyclic meditopes C-QFDLSTRRLK-C (cQFD； SEQ ID NO:1) and C-QYNLSSRALK-C (cQYN； SEQ ID NO:2) and methods for their use are provided herein. In one embodiment, a binding interface is formed by a framework region, and not a complementarity determining region (CDR), of an antibody or functional fragment thereof. In another embodiment, a therapeutic human or humanized antibody has one or more human framework residues replaced with one or more corresponding murine residues such that a meditope having the sequence cQFD or cQYN stably binds the one or more human framework residues.
