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SOLID PREPARATION COMPRISING ENTERIC SOLID DISPERSION
专利权人:
SHIN-ETSU CHEMICAL CO.; LTD.
发明人:
Takafumi Hoshino,Fumie Kusaki,Ikuo Fukui
申请号:
US14640447
公开号:
US20150238616A1
申请日:
2015.03.06
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Provided are a solid preparation comprising an enteric solid dispersion that allows a drug in the preparation to be rapidly dissolved without impairing the dissolution of the solid preparation, and a method for producing the same. More specifically, provided are a solid preparation comprising a poorly soluble drug, an enteric polymer, an excipient and a disintegrator, a mixed powder comprising at least the excipient and the disintegrator is partly or entirely covered with a solid dispersion comprising the poorly soluble dug and the enteric polymer; and a method for producing a solid preparation, comprising steps of: spraying an enteric polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a mixed powder comprising an excipient and a disintegrator; and granulating and drying a resultant.
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中国工程科技知识中心
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