PROBLEM TO BE SOLVED: To provide a solid preparation containing an enteric solid dispersion rapidly dissolving a drug in the preparation without damaging the dissolution properties of the solid preparation, or a method for preparing the same.SOLUTION: The solid preparation comprising a soluble drug, an enteric polymer, an excipient and a disintegrator comprises a granular product wherein a mixed powder comprising at least the excipient and the disintegrator is partly or entirely covered with the solid dispersion comprising a hardly soluble drug and the enteric polymer. The invention provides the solid preparation in which the release of the hardly soluble drug in the stomach is suppressed so that the dissolution rate of the hardly soluble drug using the Japanese Pharmacopoeia first liquid (artificial gastric fluid) after 120 minutes elapse is 10 mass% or less of the initial concentration of the drug administered, or a method for producing the same.COPYRIGHT: (C)2013,JPO&INPIT【課題】固形製剤の溶出性を損なうことなく、製剤中の薬物を迅速に溶出することができる腸溶性固体分散体を含む固形製剤又はその製造方法を提供する。【解決手段】溶性薬物、腸溶性ポリマー、賦形剤及び崩壊剤を含む固形製剤であって、少なくとも賦形剤及び崩壊剤を含む混合粉末の一部又は全部が、難溶性薬物と腸溶性ポリマーを含む固体分散体で被覆された造粒物を含み、日本薬局方第1液(人工胃液)での120分経過後の難溶性薬物の溶出率が薬物初期投与濃度の10質量%以下となるように難溶性薬物の胃内での放出が抑制された固形製剤又はその製造方法を提供する。【選択図】なし
