PROBLEM TO BE SOLVED: To provide an anti-prion protein antibody and antibody fragment, and an agent for the treatment or prevention of virus infection and a screening method therefor.SOLUTION: The present invention provides a monoclonal antibody or antibody fragment, which binds to prion protein, and recognizes a specific amino acid sequence as an epitope. The present invention provides a pharmaceutical composition for the treatment or prevention of virus infection, containing a prion protein regulator, and a method for screening an agent for the treatment or prevention of virus infection, the method including examining the effect of a candidate material for the prion protein regulator.SELECTED DRAWING: None【課題】抗プリオン蛋白質抗体および抗体断片、並びにウイルス感染症の治療または予防薬およびそのスクリーニング方法の提供。【解決手段】プリオン蛋白質に結合し、特定のアミノ酸配列をエピトープとして認識する、モノクローナル抗体又は抗体断片。ウイルス感染症の治療又は予防のための、プリオン蛋白質調節物質を含む医薬組成物、及び、ウイルス感染症の治療又は予防のための薬剤をスクリーニングする方法であって、プリオン蛋白質調節物質の候補物質の効果を調べることを含む方法。【選択図】なし
