Methods and compositions for amelioration of autoimmune disease using fusion proteins of anti-dendritic cell receptor antibody to peptide sequences

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专利权人:

President and Fellows of Harvard College

发明人:

Stern, Joel N.H.,Strominger, Jack L.

申请号：

AU2010303304

公开号：

AU2010303304A1

申请日:

2010.10.08

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

Compositions that are fusion proteins of antibodies to dendritic cell receptors, exemplified by anti-DEC205 and anti-33DΪ antibodies, to peptide sequences that are immunosuppressive or tolerogenic are provided for treatment of autoimmune diseases such as multiple sclerosis. Also provided are pharmaceutical compositions including the fusion proteins, as well as therapeutic methods for administering the fusion proteins.

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