Ivan Grishagin;Bogdan Olenyuk;Brooke Bullock Lau;Paramjit S. Arora
发明人:
Paramjit S. Arora,Bogdan Olenyuk,Brooke Bullock Lau,Ivan Grishagin
申请号：
US14379450
公开号：
US09255086B2
申请日:
2013.02.19
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to oligooxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF-1α. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
