ARORA, Paramjit S.,LAO, Brooke, Bullock,BONNEAU, Richard,DREW, Kevin
申请号：
EP15795595
公开号：
EP3145921A4
申请日:
2015.05.20
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The present invention relates to oxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF1α. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIFla with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
