The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.本發明提供式I化合物,製造本發明化合物之方法及其治療用途。本發明進一步提供醫藥活性劑之組合及醫藥組合物。