The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.本發明提供一種式(I)化合物或其醫藥學上可接受之鹽;一種用於製造本發明化合物的方法;及其治療用途。本發明進一步提供藥理學上活性劑的組合與醫藥組合物。