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OSTEOARTHRITIS TREATMENT AND PAIN
专利权人:
ЭББВИ ИНК. (US)
发明人:
КАМАТХ Раджеш В. (US)
申请号:
RU2013141211/15
公开号:
RU2013141211A
申请日:
2012.02.08
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method of treating pain in an individual, comprising the step of administering to the individual: a binding protein that binds to IL-1α and a binding protein that binds to IL-1β, where the binding proteins are administered to the individual in a mixture, simultaneously or sequentially; or a binding protein that binds to both IL-1α and IL-1β. 2. A method for treating pain according to claim 1, wherein the individual suffers from a pain condition selected from the group consisting of allodynia, hyperalgesia, and a combination of allodynia and hyperalgesia. 3. The method of claim 1, wherein said binding protein binding to IL-1α is an anti-IL-1α antibody. The method of claim 1, wherein said binding protein binding to IL-1β is an anti-IL-1β antibody. The method of claim 1, wherein said binding protein binding to IL-1α is an anti-IL-1α antibody and said binding protein binding to IL-1β is an anti-IL-1β antibody. The method of claim 1, wherein said binding protein that binds to both IL-1α and IL-1β is a bispecific antibody or an immunoglobulin binding protein with a double variable domain (DVD-Ig). The method of claim 1, wherein said binding protein binding to IL-1α and said binding protein binding to IL-1β are formulated in a pharmaceutical composition comprising a pharmaceutically acceptable carrier. The method of claim 1, wherein said binding protein that binds to both IL-1α and IL-1β is formulated in a pharmaceutical composition comprising a pharmaceutically acceptable carrier. The method of claim 1, wherein said binding protein binding to IL-1α and said binding protein binding to IL-1β are crystallized. The method of claim 1, wherein said binding protein is1. Способ лечения боли у индивидуума, включающий стадию введения индивидууму:связывающего белка, связывающегося с ИЛ-1α, и связывающего белка, связывающегося с ИЛ-1β, где связывающие белки вводят индивидууму в смеси, одновременно или последовательно; илисвязывающего белка, связывающегося и с ИЛ-1α, и с ИЛ-1β.2.
来源网站:
中国工程科技知识中心
来源网址:
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