ФИНЧ Донна (GB),КОЙЛ Энтони (US),СТЭМПФЛИ Мартин (CA)
申请号：
RU2012148721/10
公开号：
RU2012148721A
申请日:
2011.04.18
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method of reducing airway inflammation in a patient in need thereof, wherein said patient is a patient suffering from an exacerbation of chronic obstructive pulmonary disease (COPD), comprising administering to said patient an effective amount of a composition comprising an antibody that specifically binds to IL-1R1 and inhibits it. 2. A method for reducing IL-1α signaling in a patient in need thereof, wherein said patient is a patient suffering from an exacerbation of chronic obstructive pulmonary disease (COPD), comprising administering to said patient an effective amount of a composition comprising an antibody that specifically binds to IL-1R1 and inhibits it. 3. The method according to claim 1 or 2, characterized in that the antibody is a recombinant antibody that inhibits the binding of IL-1R1 to IL-1α. 4. The method according to claim 1 or 2, characterized in that the antibody is a recombinant antibody that inhibits the binding of IL-1R1 to IL-1β. The method according to claim 1, characterized in that the reduction of airway inflammation is part of the method of treating exacerbation of COPD. 6. The method according to claim 1, characterized in that the reduction of inflammation of the respiratory tract includes reducing the flow of neutrophils into the lung. The method according to claim 1 or 2, characterized in that the antibody has a molecular weight greater than or equal to approximately 25 kilodaltons. The method according to claim 1 or 2, characterized in that the antibody inhibits the binding of IL-1R1 to IL-1α and IL-1β. The method according to claim 1 or 2, characterized in that the said recombinant antibody is a human antibody. The method according to claim 1 or 2, characterized in that the method is part of a therapeutic regimen of leche1. Способ уменьшения воспаления дыхательных путей у пациента, нуждающегося в этом, где указанный пациент является пациентом, страдающим от обострения хронической обструктивной болезни легких (ХОБЛ), включающий в
