WANG, BING,CHU, DANIEL,LIU, YONGBO,JIANG, QUAN,LU, LEI
申请号:
SG2012056123
公开号:
SG182784A1
申请日:
2011.02.08
申请国别(地区):
SG
年份:
2012
代理人:
摘要:
Provided herein are processes for synthesizing dihydropyridophthalazinone derivatives, such as for example, 5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H- pyrido[4,3,2-de]phthalazin-3(7H)-one and its stereoisomers, which are potent poly(ADP-ribose)polymerase (PARP) inhibitors as well as novel synthetic intermediate compounds.