Aleksandr V. Yurkovetskiy,Venu R. Gurijala,Joshua D. Thomas,Timothy B. Lowinger
申请号：
US15260084
公开号：
US20170119896A1
申请日:
2016.09.08
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A terminally modified polymer is provided herein. At least one terminus of the polymer is —O—(CH2)2-LM or —O—CH2—CH(OH)—CH2—CR1═CR2R3. LM, R1, R2, and R3 are defined herein Also disclosed are terminal conjugates comprising the polymer and a pharmaceutically useful modifier, as well as compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
