SUBSTITUTED HETEROARYL DERIVATIVE, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASES WHICH CONTAINS SAME AS ACTIVE INGREDIENT
NATIONAL CANCER CENTER;재단법인 대구경북첨단의료산업진흥재단;SAMSUNG LIFE PUBLIC WELFARE FOUNDATION;사회복지법인 삼성생명공익재단;DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION;국립암센터
发明人:
CHOI, Hwan Geun,최환근,KIM, Dayea,김다예,LEE, Sun Joo,이선주,KIM, Sang Bum,김상범,PARK, Jong Bae,박종배,NAM, Do-Hyun,남도현,KO, Eunhua,고은화,PARK, Jin-Hee,박진희,KO, Yi Kyung,고이경,KANG, Seock Yong,강석용,KIM, So Young,김소영,JANG,
申请号：
KRKR2019/010369
公开号：
WO2020/036437A1
申请日:
2019.08.14
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention pertains to: a substituted heteroaryl derivative； a method for producing same； and a pharmaceutical composition which contains same as an active ingredient and is for preventing or treating protein kinase-related diseases. Since the substituted heteroaryl derivative has excellent inhibitory activity against various protein kinases including LRRK2, a pharmaceutical composition containing the substituted heteroaryl derivative as an active ingredient can be useful for treating or preventing protein kinase-related diseases.La présente invention concerne : un dérivé hétéroaryle substitué ； un procédé de production de celui-ci ； et une composition pharmaceutique le contenant en tant que principe actif pour la prévention ou le traitement de maladies liées à la protéine kinase. Le dérivé hétéroaryle substitué a une excellente activité inhibitrice vis-à-vis de diverses protéines kinases y compris LRRK2, la composition pharmaceutique contenant le dérivé hétéroaryle substitué en tant que principe actif peut ainsi être utile dans le traitement ou la prévention de maladies liées à la protéine kinase.치환된 헤테로아릴 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 상기 치환된 헤테로아릴 유도체는 LRRK2를 포함하는 다양한 단백질 키나아제에 대한 억제활성이 우수하므로, 이를 유효성분으로 함유하는 약학적 조성물은 단백질 키나아제 관련 질환의 치료 또는 예방에 유용하게 사용될 수 있다.
