COMPOSÉ DÉRIVÉ DE PYRROLO-PYRIDINE, SON PROCÉDÉ DE PRÉPARATION ET COMPOSITION PHARMACEUTIQUE LE CONTENANT EN TANT QUE PRINCIPE ACTIF POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES ASSOCIÉES À LA PROTÉINE KINASE
Korea Research Institute of Bioscience and Biotechnology;Daegu Gyeongbuk Institute of Science and Technology;Daegu-Gyeongbuk Medical Innovation Foundation
发明人:
申请号：
EP18770572.8
公开号：
EP3604304A1
申请日:
2018.03.23
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.
