ХОНГ Сунг Хи (KR),ЛИ Биунг Сун (KR),ИМ Дае Сеонг (KR),ЛИ Дзае Мин (KR),БАЕ Сунг Мин (KR),КВОН Се Чанг (KR)
申请号：
RU2013106276/15
公开号：
RU2013106276A
申请日:
2011.07.14
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A liquid formulation of human growth hormone conjugate depot comprising a pharmaceutically effective amount of a conjugate of human growth hormone with prolonged action, wherein the human growth hormone linked to the immunoglobulin Fc-region and containing albumin stabilizer, wherein said stabilizer comprises a buffer pH 5,0- 6.0, a sugar alcohol, a nonionic surfactant and sol.2. The liquid formulation of human growth hormone conjugate depot according to Claim. 1, wherein the sugar alcohol is selected from the group consisting of mannitol, sorbitol and sochetaniya.3. The liquid formulation of human growth hormone conjugate depot according to Claim. 1, wherein the sugar alcohol is used in an amount of from 1 to 10% (wt. / Vol.) Of total sostava.4. The liquid formulation of human growth hormone conjugate depot according to Claim. 1, wherein the buffer is a citrate or phosphate bufer.5. The liquid formulation of human growth hormone conjugate depot according to Claim. 1 wherein the pH buffer is in the range from 5.2 to 6,0.6. The liquid formulation of human growth hormone conjugate depot according to Claim. 1 wherein the pH buffer is in the range from 5.2 to 5,5.7. The liquid formulation of human growth hormone conjugate depot according to Claim. 1, wherein the salt is a chloride natriya.8. The liquid formulation of human growth hormone conjugate depot according to Claim. 1, wherein the salt is used in a concentration of from 5 to 200 mM.9. The liquid formulation of human growth hormone conjugate depot according to Claim. 1, wherein the nonionic surfactant is polysorbate 80.10. The liquid formulation of human growth hormone conjugate Prolong1. Жидкий состав конъюгата гормона роста человека пролонгированного действия, содержащий фармацевтически эффективное количество конъюгата гормона роста человека пролонгированного действия, в котором гормон роста человека связан с Fc-областью иммуноглобулина, и не содержащий альбумин стабилизатор, где указанный стабилизатор содерж
