БАННИСТЕР Робин Марк (GB),БРЮ Джон (GB),ДИЛЛИ Сьюзанн Джейн (GB),СТОЛОФФ Грегори Алан (GB),КАПАРРОС-ВАНДЕРЛЕЙ Уилсон (GB)
申请号：
RU2013140775/15
公开号：
RU2013140775A
申请日:
2012.02.03
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A pharmaceutical composition comprising: a) a therapeutic compound having activity that normalizes lipid levels, where the therapeutic compound has a log P value greater than 2.0, b) a pharmaceutically acceptable solvent, and c) a pharmaceutically acceptable adjuvant, where the adjuvant is, at least 80% (v / v) of the pharmaceutical composition. 2. The pharmaceutical composition according to claim 1, wherein the activity that normalizes lipid levels has anti-hyperlipidemic activity, reduces the level of the molecule that causes inflammation, reduces the level of the prostaglandin that causes inflammation, stimulates the PPAR signaling pathway, induces apoptosis of macrophage M1 cells, activates the differentiation of macrophage M2 cells or both of them reduce the levels of interferon-gamma (IFNγ), tumor necrosis factor-alpha (TNF-α), interleukin-12 (IL-12), or a combination of them released from Th1 cells, increases the levels of IL-10, released expected from Th2 cells, or both. 3. The pharmaceutical composition according to claim 2, wherein the anti-hyperlipidemic activity reduces the levels of VLDLP, LPP, LDL or a combination thereof by at least 10% and / or increases the level of HDL, for example, by at least 2%. The pharmaceutical composition according to claim 1, wherein the therapeutic compound comprises a non-steroidal anti-inflammatory drug (NSAID), a PPARγ agonist； a nuclear receptor binding agent, an anti-hyperlipidemic agent and / or an ether thereof. 5. The pharmaceutical composition according to claim 4, where the NSAIDs include NSAIDs - a derivative of a salt or ester of salicylic acid, NSAIDs - a derivative of p-aminophenol, NSAIDs - a derivative of propionic acid, NSAIDs - a derivative of acetic acid, NSAIDs - derivative en1. Фармацевтическая композиция, содержащая:a) терапевтическое соединение, обладающее активностью, которая нормализует уровни липидов, где терапевтическое соединение имеет значение log P, большее, чем 2,0；b) фармацевтически прием
