SATU VAINIKKA,GEORGE STEVEN MORRIS,SAMUEL OGUNSALU,ANTIMO MIGLIACCIO,GABRIELLA CASTORIA,FERNANDO AURICCHIO
申请号：
GB201307872
公开号：
GB2513615A
申请日:
2013.05.01
申请国别(地区):
GB
年份:
2014
代理人:
摘要：
A molecule that modulates an activity of a Src family kinase for use in preventing or treating a metastatic cancer in a subject. Preferably, the molecule comprises the structure: Bj-[(Pro)n-Xr-His-Pro-His-Ala-Arg-Ile-Lys]m-Rp or, Bj-[lys-ile-arg-ala-his-pro-his-xr-(pro)n]m-ÂRp, or a derivative or fragment thereof, wherein B is a first chemical moiety, j is 0 or 1, n is an integer from 1-10, X is any amino acid, r is an integer from 0 to 2, m is an integer from 1 to 3, R is a second chemicalmoiety and p is 0 or 1. Also claimed is a composition comprising such a molecule and a therapeutic agent suitable for preventing or treating a metastatic cancer； a method of selecting an agent to prevent or treat a metastatic cancer comprising determining whether a test agent modulates an activity of a Src family kinase.
