VAINIKKA, Satu,MORRIS, George Steven,OGUNSALU, Samuel,CASTORIA, Gabriella,MIGLIACCIO, Antimo,AURICCHIO, Fernando
申请号：
AU2019229363
公开号：
AU2019229363A1
申请日:
2019.09.11
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
#$%^&*AU2019229363A120191003.pdf#####ABSTRACT The invention provides a molecule that modulates an activity of a Src family kinase for use in preventing or treating a metastatic cancer a subject. Preferably, the molecule comprises 5 or consists of the structure: Bj-[(Pro)-XcHis-Pro-His-Ala-Arg-le-Lys]m-Rp, or Bj-[ys-ile-argala-his-pro-his-xc(pro)n]m-Rp, or a derivative or fragment thereof, wherein B is a first chemical moiety, j is 0 or 1, n is an integer from 1-10, X is any amino acid, r is an integer from 0 to 2, m is an integer from 1 to 3, R is a second chemical moiety, p is 0 or 1, and [lys-ile-arg-ala-his-pro-his-xc(pro)n] is the retro-inverso peptide of [(Pro)-XHis-Pro-His10 Ala-Arg-Ile-Lys]. /11C:
