David QUINTANAR GUERRERO,Esteban Abdiel CAMACHO ORTIZ,Citlalli ALONSO REYES
申请号：
MX2013013306
公开号：
MX347181B
申请日:
2013.11.14
申请国别(地区):
MX
年份:
2017
代理人:
摘要：
Described is a process for obtaining a co-processed excipient for the release of active substances that comprises the following steps: (a) locating a functional excipient in a container for the direct compression thereof in an amount ranging from 5g/L to 500 g/L (b) adding a dispersion of nanoparticles in a content of solids that depends on the functional excipient of direct compression of: 1:1, 1:0.9, 1:0.8, 1:0.7, 1:0.6, 1:0.5, 1:0.4, 1:0.3, 1:0.2, 1:0.1 (c) adjusting to 1 Lt of constant volume with water, where said water amount will depend on the weight of the functional excipient of direct compression, and the container (d) maintaining under constant mechanical agitation the composition for 24 hours in order to perform the assembling process by means of the polymer adsorption over the functional excipient of direct compression (e) letting to rest the composition for a period of 24 hours (f) decanting the solids settled in the container (g) drying the excess of humidity at a temperature ranging from 30°C to 40°C, using any furnace drying method, using spray drying and (h) sieving the collected powders with the purpose of homogenizing the particle size to be compressed, being sieved in meshes of 50, 60 or 70.Se describe un proceso para la obtención de un excipiente co-procesado para la liberación de sustancias activas que comprende las etapas de: (a) colocar en un contenedor un excipiente funcional para compresión directa en una cantidad que va desde 5g/L hasta 500 g/L (b) adicionar una dispersión de nanopatrtículas en una proporción de sólidos con respecto al excipiente funcional para compresión directa de: 1:1, 1:0.9, 1:0.8, 1:0.7, 1:0.6, 1:0.5, 1:0.4, 1:0.3, 1:0.2, 1:0.1 (c) ajustar a 1 Lt de volumen constante con agua, en donde dicha cantidad de agua va a estar en función tanto del peso del excipiente funcional para compresión directa, así como del contenedor (d) mantener bajo agitación mecánica constante durante 24 horas a fin de llevar a cabo el proceso de
