Crystalline forms of the hydrochloride Salt of (4th - 9th - (R, S) - 1 - (1H - served - 5 - carbonyl - 2,3,4,4a, 9,9a - hexahidro inden - 1H - [2,1-b] pyridin - 6 - carbonitrilo and their use as inhibitors of HSD 1
The present Invention relates to compounds defined by formula I in which the variables R1, R2, R3, R4 and M are defined as in claim 1, which have important pharmacological activity.In particular, the compounds are inhibitors of 11 hydroxysteroid dehydrogenase (HSD) 1 and, therefore, are suitable for the treatment and Prevention of diseases which can be influenced by inhibition of this Enzyme, such as Metabolic Diseases, particularly diabetes type 2, Obesity and dyslipidemia.La presente invención se refiere a compuestos definidos por la fórmula I en la que las variables R1, R2, R3, R4 y m se definen como en la reivindicación 1, que tienen actividad farmacológica importante. En particular, los compuestos son inhibidores de 11 -hidroxiesteroide deshidrogenasa (HSD) 1 y, por lo tanto, son adecuados para el tratamiento y prevención de enfermedades que pueden verse influidas por la inhibición de esta enzima, tal como enfermedades metabólicas, en particular diabetes tipo 2, obesidad y dislipidemia.
