FORMAS CRISTALINAS DE LA SAL CLORHIDRATO DE (4A-R,9A-S)-1-(1H-BENZOIMIDAZOL-5-CARBONIL)-2,3,4,4A,9,9A-HEXAHIDRO-1H-INDEN[2,1-B]PIRIDIN-6-CARBONITRILO Y SU USO COMO INHIBIDORES DE HSD 1农业专利-农业学术服务平台

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FORMAS CRISTALINAS DE LA SAL CLORHIDRATO DE (4A-R,9A-S)-1-(1H-BENZOIMIDAZOL-5-CARBONIL)-2,3,4,4A,9,9A-HEXAHIDRO-1H-INDEN[2,1-B]PIRIDIN-6-CARBONITRILO Y SU USO COMO INHIBIDORES DE HSD 1

专利权人:: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

发明人:: ECKHARDT, MATTHIAS,MARTIN, HANS-JUERGEN,SCHUEHLE, MARTIN,SICK, SANDRA,YANG, BING-SHIOU

申请号：: PE0009492013

公开号：: PE01232014A1

申请日:: 2011.11.04

申请国别(地区):: PE

年份:: 2014

代理人:

摘要：: Relates to Crystalline forms of a compound of formula (ii) is the hydrochloride Salt of (4th - 9th - (R, S) - 1 - (1H - served - 5 - carbonyl) - 2,3,4,4a, 9,9a - hexahidro inden - 1H - [2,1-b] pyridin - 6 - carbonitrilo, such as: The Crystal form i) whose Peaks of x-ray Powder diffraction Angles 2tetha s On 12.5\ufffd, 12.9\ufffd, 14.8\ufffd, 20,0\ufffd, 22.2\ufffd and 26.1 and whose Peaks of 13C Solid State Nuclear magnetic resonance are 142.8 146.5 170.3 ppm ppm ppm, 135.0 ppm, 130.6 ppm 128.1 ppm, 122.1 ppm ppm, 116.7, among others and (b) The Crystalline Form II whose Peaks of x-ray Powder diffraction Angles are 2tetha 13.7\ufffd, 17.6\ufffd 19.7\ufffd,, 21.3\ufffd, 21,9\ufffd, 23.3\ufffd, 25.6\ufffd, 26.5, among others and whose Peaks of 13C Solid State Nuclear magnetic resonance are 172.6 147.1 144.1 ppm ppm ppm, 132.9 ppm 129.6 ppm, 125.9 121.2 119.5 ppm ppm ppm, among others. This Compound is an inhibitor of the Enzyme 11b hydroxysteroid dehydrogenase (HSD) 1 being useful in the treatment of Type 2 diabetes, obesity, dyslipidemiaSE REFIERE A FORMAS CRISTALINAS DEL COMPUESTO DE FORMULA (II) QUE ES LA SAL CLORHIDRATO DE (4a-R,9a-S)-1-(1H-BENZOIMIDAZOL-5-CARBONIL)-2,3,4,4a,9,9a-HEXAHIDRO-1H-INDEN[2,1-b]PIRIDIN-6-CARBONITRILO, TALES COMO: A) LA FORMA CRISTALINA I CUYOS PICOS DE DIFRACCION DE RAYOS X EN POLVO A ANGULOS 2TETHA SON 12.5�, 12.9�, 14.8�, 20,0�, 22.2� Y 26.1� Y CUYOS PICOS DE RESONANCIA MAGNETICA NUCLEAR 13C EN ESTADO SOLIDO SON 170.3 ppm, 146.5 ppm, 142.8 ppm, 135.0 ppm, 130.6 ppm, 128.1 ppm, 122.1 ppm, 116.7 ppm, ENTRE OTROS Y B) LA FORMA CRISTALINA II CUYOS PICOS DE DIFRACCION DE RAYOS X EN POLVO A ANGULOS 2TETHA SON 13.7�, 17.6�, 19.7�, 21.3�, 21,9�, 23.3�, 25.6�, 26.5�, ENTRE OTROS Y CUYOS PICOS DE RESONANCIA MAGNETICA NUCLEAR 13C EN ESTADO SOLIDO SON 172.6 ppm, 147.1 ppm, 144.1 ppm, 132.9 ppm, 129.6 ppm, 125.9 ppm, 121.2 ppm, 119.5 ppm, ENTRE OTROS. DICHO COMPUESTO ES INHIBIDOR DE LA ENZIMA 11B-HIDROXIESTEROIDE DESHIDROGENASA (HSD) 1 SIENDO UTIL