您的位置: 首页 > 农业专利 > 详情页

MODULATEURS P2X7
专利权人:
Janssen Pharmaceutica NV
发明人:
申请号:
EP17199037.7
公开号:
EP3309161A1
申请日:
2014.03.14
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention is directed to a compound of Formula (I): wherein: n is an integer from 0-1; • X is CH2 when n is 0, or X is CH2 or oxygen when n is 1; • R1 is phenyl or pyridinyl, wherein the phenyl or pyridinyl is optionally substituted with from 1 to 4 substituents independently selected from halogen and alkyl; and • R2 is phenyl, pyridinyl, pyrazinyl, pyradizinyl, pyrimidinyl, pyrrolyl, pyrazolyl, thiazolyl or thiophenyl, wherein the phenyl, pyridinyl, pyrazinyl, pyradizinyl, pyrimidinyl, pyrrolyl, pyrazolyl, thiazolyl or thiophenyl is optionally substituted with from 1 to 2 substituents independently selected from the group consisting of halogen, alkyl, hydroxy and alkoxy. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). The compounds of formula (I) are useful as P2X7 modulators.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充