Derivatives of 17-hydroxy-17-pentafluoroethyl-estra-4,9 (10) -dien-11-acyloxyalkylenephenyl, process for its preparation and use for the treatment of diseases
Compound of formula I ** Formula ** in which X means oxygen, a group NOR3 or>； = NNHSO2R3, R1 means C1-C10 alkyl, (CH2) nY or CHR4NR5PG, R2 means hydrogen or C1-C10 alkyl, R3 means hydrogen, C1-C10 alkyl, aryl or C7-C20 aralkyl, n means 1 to 10, Y means hydrogen, aryl, heteroaryl R4, R5 independently of each other hydrogen, C1-C10 alkyl, C7-C10 aralkyl, or together they are a group (CH2) m- or a group CH2CHOHCH2, m means 3 or 4 and PG means hydrogen or an amino protecting group and its salts, solvates or solvates of the salts, including all crystalline modifications, the α-, β- or γ- cyclodextrinctratrates, as well as compounds encapsulated with liposomes in which Aryl represents an aromatic, substituted or unsubstituted monocyclic tricyclic carbocyclic radical, which may be substituted once or several times with halogen (F, Cl, Br, I) , OH, O-alkyl, CO2H, CO2 alkyl, NH2, NH (C1-C10 alkyl), N (C1-C10 alkyl ) 2, in particular groups N (CH3) 2, NO2, N3, CN, C1-C10 alkyl, C2-C10 alkylene, C2-C10 alkynyl, perfluoro-C1-C10 alkyl, C1-C10 acyl, C1-C10 acyloxy. Heteroaryl represents an aromatic, mono- or bicyclic radical with as a rule 5 to 10 ring atoms and up to 5 heteroatoms of the S, O and N series, for example, which may be substituted once with C1-C4 alkyl. Aralkyl represents aralkyl groups, and may be substituted once or several times by halogen, OH, alkyl groups O, CO2H, alkyl-CO2, NH2, NH (C1-C10 alkyl), N (C1-C10 alkyl) 2, NO2, N3 , CN, C1-C20 alkyl, C1-C10 perfluoroalkyl, C1-C20 acyl, C1-C20 acyloxy groups.Compuesto de la fórmula I**Fórmula** en la cual X significa oxígeno, un grupo NOR3 o >；=NNHSO2R3, R1 significa alquilo C1-C10, (CH2)n-Y o CHR4NR5PG, R2 significa hidrógeno o alquilo C1-C10, R3 significa hidrógeno, alquilo C1-C10, arilo o aralquilo C7-C20, n significa 1 a 10, Y significa hidrógeno, arilo, heteroarilo R4, R5 significan independientemente uno de otro hidrógeno, alquilo C1-C10, aralquilo C7-C10, o juntos son un grupo (CH2)m- o un grupo CH2CHOHC
