COMPOSES 2-OXOTHIAZOLES ET 2-OXOTHIOPHENES ANTI-INFLAMMATOIRES ET ANTITUMORAUX

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专利权人:

AVEXXIN AS

发明人:

JOHANSEN, BERIT,SANDBERG, MARCEL,AUKRUST, INGER-REIDUN,KOKOTOS, GEORGE,BARBAYIANNI, EFROSINI

申请号：

CA2899137

公开号：

CA2899137A1

申请日:

2014.01.28

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

A compound of formula (I) wherein X is O, C O or S； Y is N or CH； R2 and R4 are each independently H, -(CH2)pCOOH, -(CH2)pCON(R5)2 or - (CH2)pCOOC 1-6alkyI； or R2 and R4 together form a 6-membered phenyl ring fused to the five membered ring； each R1 is independently selected from H, halo (e.g. fluoro or chloro), C6-10aryl, C7-12arylalkyl, C2-12alkenyl； OC1-2 alkyl, OC2-12 aikenyl or a C1-12 alkyl group； each R5 is H or C1-6 alkyl； each p is 0 to 3； n is 1 to 4； or a salt, ester, solvate, N-oxide, or prodrug thereof, e.g. a salt thereof.

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