Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with pi 105 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelodysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.L'invention concerne des hétéroaryles bicycliques substitués et des compositions les contenant pour le traitement d'une inflammation générale, de l'arthrite, de maladies rhumatismales, de l'arthrose, de maladies intestinales inflammatoires, de troubles oculaires inflammatoires, de troubles inflammatoires de la vessie ou de l'instabilité vésicale, du psoriasis, de problèmes cutanés à composantes inflammatoires, d'états inflammatoires chroniques, comprenant, mais sans y être limités, des maladies auto-immunes, telles que le lupus érythémateux disséminé (SLE), la myasthénie grave, la polyarthrite rhumatoïde, l'encéphalomyélite aiguë disséminée, le purpura thrombopénique idiopathique, la sclérose en plaques, le syndrome de Sjoegren et l'anémie hémolytique auto-immune, d'états allergiques comprenant toutes formes d
