Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110&delta； activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.L'invention concerne des hétéroaryles bicycliques substitués et des compositions les contenant, pour le traitement d'une inflammation générale, de l'arthrite, de maladies rhumatismales, de l'arthrose, de troubles inflammatoires intestinaux, de troubles oculaires inflammatoires, de troubles inflammatoires ou de vessie instable, du psoriasis, d'affections cutanées avec composantes inflammatoires, d'états inflammatoires chroniques, y compris mais de façon Non limitative, les maladies auto-immunes telles que le lupus érythémateux disséminé (LED), la myasthénie grave, l'arthrite rhumatoïde, l'encéphalomyélite aiguë disséminée, le purpura thrombocytopénique idiopathique, la sclérose en plaques, le syndrome de Sjögren et l'anémie hémolytique auto-immune, les états allergiques comprenant toutes formes d'hypersen
