PROBLEM TO BE SOLVED: To provide new means for developing an APL therapeutic agent capable of inducing differentiation of an APL cell to a normal cell such as a neutrophilic cell.SOLUTION: A screening method of therapeutic agent for acute promyelocytic leukemia comprising measuring expression of SIRT2 gene product in an acute promyelocytic leukemia cell in the presence of a test ingredient.COPYRIGHT: (C)2014,JPO&INPIT【課題】APL細胞を好中球様細胞等の正常細胞に分化誘導できるAPL治療薬開発のための新たな手段の提供。【解決手段】被験成分の存在下に、急性前骨髄球性白血病細胞における、SIRT2遺伝子産物の発現性を測定することを特徴とする急性前骨髄球性白血病治療薬のスクリーニング方法。【選択図】なし
