Ronald P. Gladue,Bradley T. Keller,Shinji Ogawa,Arvind Rajpal,Laurie A. Tylaska,Shelley Sims Belouski,Larry L. Green,Meina Liang
申请号：
US14244167
公开号：
US09238691B2
申请日:
2014.04.03
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided are antibodies including human antibodies and antigen-binding portions thereof that specifically bind to CCR2, preferably human CCR2, and that may inhibit CCR2. The present antibodies may bind to the first and/or second extracellular loops of CCR2. Isolated heavy and light chains derived from the antibodies and nucleic acid molecules encoding the antibodies and chains are provided. Methods of making and using the anti-CCR2 antibodies or antigen-binding portions, and compositions comprising these antibodies or antigen-binding portions, including compositions for diagnosis and treatment, are provided. Also provided are gene therapy methods using nucleic acid molecules encoding the heavy and/or light chains that comprise the human anti-CCR2 antibodies or antigen-binding portions thereof.
