GREEN, Larry L.,GLADUE, Ronald P.,KELLER, Bradley T.,RAJPAL, Arvind,TYLASKA, Laurie A.,BELOUSKI, Shelley Sims,LIANG, Meina,OGAWA, Shinji
申请号：
DK09789161
公开号：
DK2321351T3
申请日:
2009.08.17
申请国别(地区):
DK
年份:
2017
代理人:
摘要：
Provided are antibodies including human antibodies and antigen-binding portions thereof that specifically bind to CCR2, specifically human CCR2, and that may function to inhibit CCR2. Anti-CCR2 antibodies include those which bind to the first and/or second extracellular loops of CCR2. Also provided are human anti-CCR2 antibodies and antigen-binding portions thereof. Isolated heavy and light chain immunoglobulins derived from human anti-CCR2 antibodies and nucleic acid molecules encoding such immunoglobulins are provided. Methods of making human anti-CCR2 antibodies or antigen-binding portions, compositions comprising these antibodies or antigen-binding portions, methods of using the antibodies and antigen-binding portions, and compositions for diagnosis and treatment are provided. Also provided are gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CCR2 antibodies or antigen binding portions thereof.
