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BISPHOSPHONIC ACID DERIVATIZED OF LIPIDS.
专利权人:
MCS MICRO CARRIER SYSTEMS GMBH
发明人:
GREB, WOLFGANG,SHYHSKOV, OLEG,ROESCHENTHALER, GERD-VOLKER,HENGST, VERENA
申请号:
ES05714898
公开号:
ES2375060T3
申请日:
2005.01.24
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
Bisphosphonic acid with the general formula (I) ** Formula ** in which R1 is OH, X is: (CH2) m- (OCR3HCH2) n- (O) or- in which R3 means H or CH3 and m represents 0 or a number from 1 to 6, n a number from 1 to 10, especially 1 to 6, I represents 0 or 1, - (CR4HCH2O) p- in which R4 means H or CH3, p represents a number from 1 to 10 , especially 1 to 6, or (CH2) q- (OCR5HCH2) r- (O) s- (CH2) t- in which R5 means H or CH3, and q represents 0 or a number from 1 to 6, r represents a number from 1 to 10, especially 1 to 6, and s represents 0 or 1 and t represents a number from 1 to 6, R2 is a moiety with the formula (II) ** Formula ** as well as its physiologically acceptable salts and trimethylsilyl derivativesÁcido bisfosfónico con la fórmula general (I) **Fórmula** en la que R1 es OH, X es: (CH2)m-(OCR3HCH2)n-(O)o- en la que R3 significa H o CH3 y m representa 0 o un número de 1 a 6, n un número de 1 a 10, especialmente 1 a 6, y o representa 0 ó 1, -(CR4HCH2O)p- en la que R4 significa H o CH3, p representa un número de 1 a 10, especialmente 1 a 6, o (CH2)q-(OCR5HCH2)r-(O)s-(CH2)t- en la que R5 significa H o CH3, y q representa 0 o un número de 1 a 6, r representa un número de 1 a 10, especialmente 1 a 6, y s representa 0 ó 1 y t representa un número de 1 a 6, R2 es un resto con la fórmula (II) **Fórmula** así como sus sales fisiológicamente aceptables y derivados de trimetilsililo
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