COMBS, RODNEY GENE,ROE, SUSANNA,RUBLE, DERRICK LEE
申请号：
CA2757079
公开号：
CA2757079C
申请日:
2010.04.15
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention relates to novel methods for controlling the glycosylation of aprotein and the protein producedthereby. An exemplary method of the invention comprises producing a proteincomprising a decreased level of glycosylation, e.g.,the protein comprises fewer glycans or fewer saccharides at the glycosylationsite, by culturing a host cell expressing the protein inthe presence of a glycosylation inhibitor. In an exemplary method of theinvention, the biological characteristics of the protein arealtered by the decreased level of glycosylation, e.g., the binding of theprotein with its target ligand is modified.
