Grant Gallagher;Raymond Yu;Joyce Eskdale;Jonathan Brazaitis
发明人:
Grant Gallagher,Raymond Yu,Joyce Eskdale,Jonathan Brazaitis
申请号：
US13065867
公开号：
US09523073B2
申请日:
2011.03.31
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A naturally-occurring soluble truncated IL-23Rα protein (i.e., Δ9 IL-23Rα) is shown to be present in a biological sample and can serve as a diagnostic tool for autoimmune diseases. There is provided an enzyme-linked immunosorbent assay (ELISA) and test kit for the serological detection of the soluble truncated form of IL-23Rα protein. More particularly, antibody-sandwich ELISA method and kits for Δ9 IL-23Rα as an antigen were developed to detect Δ9 IL-23Rα levels in biological samples from a mammal and a human patient and are used as a diagnostic index. The present disclosed ELISA has utility as a diagnostic tool to detect Crohn's disease in patients using EDTA-plasma.
