PROBLEM TO BE SOLVED: To provide a blending change prediction method capable of more accurately grasping an appearance change for pH fluctuation with respect to a diluted parenteral solution.SOLUTION: A blending change prediction method for predicting a blending change in a prescription in which a plurality of medicines including a first medicine are blended includes: a first process for blending the first medicine and an infusion solution at a prescription dosage ratio to acquire a blended solution a second process for acquiring relationships between the solubility and the pH of the first medicine for the infusion solution based on the pH change of the blended solution a third process for calculating the pH (P1) of a prescription solution in which all the medicines in the prescription are blended and a fourth process for predicting an appearance change of the blended solution based on the relationships between the solubility and the pH of the first medicine for the infusion solution, and the pH (P1) of the prescription solution.COPYRIGHT: (C)2014,JPO&INPIT【課題】希釈した注射液についてpH変動に対する外観変化をより正確に把握することができる配合変化予測手法を提供すること。【解決手段】第1薬剤を含む複数の薬剤を配合する処方において配合変化を予測する配合変化予測方法であって、前記第1薬剤と輸液とを処方用量比で配合して配合液を得る第1工程と、前記配合液のpH変動に基づいて前記輸液に対する前記第1薬剤の溶解性とpHとの関係を得る第2工程と、前記処方内の薬剤全てを配合した処方液のpH(P1)を算出する第3工程と、前記輸液に対する前記第1薬剤の溶解性とpHとの関係と、前記処方液のpH(P1)とに基づいて前記配合液の外観変化を予測する第4工程と、を有する。【選択図】図1
