FRANCOIS THARRAULT,CECILE POIRIER,GILLES FONKNECHTEN,JEAN MANUEL PEAN
申请号：
FR1102500
公开号：
FR2978916B1
申请日:
2011.08.10
申请国别(地区):
FR
年份:
2013
代理人:
摘要：
Solid oral composition comprises agomelatine or its hydrate, complexes, co-crystals, crystalline forms, addition salts with an acid or a base, and one or more excipients comprising diluents, binders, flowing agents, lubricants, coating agents, plasticizers, flavors, anti-irritants or sweeteners, where the composition has: an absolute bioavailability of greater than 25%； and a bioavailability greater than that obtained for an orodispersible tablet with an oromucosal absorption containing the active principle agomelatine under the same form and at the same dosage. ACTIVITY : Antidepressant； Tranquilizer； Neuroleptic； Hypnotic； Cardiovascular-Gen.； Gastrointestinal-Gen.； CNS-Gen.； Muscular-Gen.； Anorectic. MECHANISM OF ACTION : None given.
