Provided herein are pharmaceutical formulations, methods,and systems for the cosmetic alteration of fat deposits. Methods compriseadministering a pharmaceutical formulation of a long-acting beta-2 adrener-gicreceptor agonist, for example, salmeterol, that is suitable for subcuta-neousadministration. Methods further comprise administering a pharma-ceuticalformulation that is suitable for subcutaneous injection comprising:(a) a lipophilic long-acting selective beta-2 adrenergic receptor agonistand/orglucocorticosteroid, or a salt, optical isomer, racemate, solvate, or poly-morphthereof； and (b) at least one subcutaneously acceptable inactive in-gredient
