Proposition 1: A compound (1) and (2)And salts, isomers and starches which are acceptable medically in formula (1) A = N, or S.The value in a = n formula (2)；B = C, N, C = N, or formula (1),C = n (2) in the formula；X = CH832222；S, NH, O, CD832222；N = 0,1； in the case of N = 1, carbon atoms can be replaced by independently selected r 12 and R 1 cubes including H, D, I, phenyl, F and OH or together with R 2 and R 3, which can form saturated cyclic residues, preferably cyclopropane, cyclopentane or C. E. If N = 1, R8310 may not be present； R830808 = R8309 = H, F； R1 may not be present or selected from groups containing - H, - NH832222；1. C83218331 and 832431 leased land；1. Phenyl, with one or more halogens, Arilalquilo, Cyclolalquilo, methyl furan, tetraethylbenzene oxide, tetrahydrofuran-2-IL-methyl, 3-(diethyl) propyl, 2-methoxy, ethylene, 2-(methyl sulfide) ethyl, 1-cyclopropyl ethyl ester, pyridine-2-ILO (pyridine-3-IL) methyl, 2-(pyridine-2-IL) ethyl, 2-(thiophene) - 2-il) ethyl, 3,4-dimethoxyphenyl, 4-methoxyphenyl, 4-chloro-5-(morphine-4-sulfur) phenyl, 4-[(difluoromethyl) sulfur) phenyl, 4-(morphine-4-sulfur) phenyl, 4-(morphine-sulfur) phenyl, 5-(dimethylsulfur) -2-methylphenyl, 3-(trifluoromethyl) phenyl, 4-(trifluoromethyl) phenyl, 2-(morphine-4-(ethyl) phenyl) 1. Pilo, 1-naftyl, 2, 3-dihydro-1, 4-benzodioxin-6-ilo, benzhidril, 5-ind Nile, tiofeno and methyl thiophene；R 2 does not exist or change from H, alkyl, cyclopentyl, cyclopentyl-methyl, heteromorphic, phenyl, phenyl to one or more halogens, phenyl to one or more alcoys, phenyl to one or more nitro, benzene to one or more nitro, benzene, to one or more alkyl groups, (2.2-difluoropropyl) Methyl, 2-bromo-3-fluoro (2,2-dimethylpropyl) methyl, 4-hydroxyphenyl, 2-(Benciloxi) ethyl, 2-bromo-4-methoxyphenyl, 2-methyl-quilin, 3-methylpyridine-4-International Labour Organization, 4-methyl-phenyl-2-methyl phenyl, 2-chloro-4, 6-dinitrobenyl, 1,3-phenyl-diazo-5-methyl, 2-phenyl E. From H, alcoxiarilo, phenyl and p
