David PUTNAM,Hannah C. WATKINS,Matthew P. DELISA,Gary R. WHITTAKER,Cassandra GUARINO
申请号：
US16498864
公开号：
US20200054571A1
申请日:
2018.03.29
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to a microparticle. The microparticle includes one or more recombinant outer membrane vesicles, at least some of which display a fusion protein, where the fusion protein comprises at least a portion of a transport protein coupled to at least a portion of one or more antigenic proteins or peptides, and a polymeric coating over the one or more recombinant outer membrane vesicles. The present invention further relates to a method of eliciting an immune response in a mammal and a method of making encapsulated outer membrane vesicles displaying a fusion protein.
