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Methylpyrrolopyrimidinecarboxamides
专利权人:
TAKEDA GMBH
发明人:
STADLWIESER, JOSEF,SCHMIDT, BEATE,BERNSMANN, HEIKO,DUNKERN, TORSTEN,BENEDIKTUS, EWALD,PAHL, ANDREAS,HUSSONG, RAGNA,NIMZ, OLAF,MÜLLER, MATTHIAS,VIERTELHAUS, MARTIN
申请号:
ES10744949
公开号:
ES2529563T3
申请日:
2010.08.24
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compound of formula (I) ** Formula ** in which R1 is -CH2-C3-6 cycloalkyl or C1-4 alkyl optionally substituted with R11, R11 is C1-4 alkoxy or hydroxy, R2 is hydrogen or alkyl of C1-4 R21 is hydrogen or fluoro, R22 is hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, hydroxy, C1-4 fluoroalkoxy, -C (O) -C 1-4 alkyl or fluoroalkyl of C1-4, or R21 and R22 combine to form a group -O-CH2-O-, R23 is hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, hydroxy or C1-4 fluoroalkoxy, or R22 and R23 combine to form a group -O-CH2-O-, R24 is hydrogen, Y is - (CH2) n-, n is 0 or 1, R3 is a 4- to 7-membered saturated heterocyclic ring containing an atom of nitrogen and optionally an oxygen atom, said heterocyclic ring being optionally substituted with R4 and / or with one or two substituents R5, or a C3-6 cycloalkyl group substituted with R6 and optionally substituted with R61, R4 is -C (O ) -H, -C (O) -C 1-4 alkyl, in which the gr or C1-4alkyl is optionally substituted with R41, -C (O) -C3-6cycloalkyl, wherein the C3-6 cycloalkyl group is optionally substituted with R42, or -C (O) -O-alkyl C1-4, in which the C1-4 alkyl group is optionally substituted with R43, R41 is C1-4 alkoxy or hydroxy, R42 is C1-4 alkoxy or hydroxy, R43 is C1-4 alkoxy or hydroxy , if only one R5 substituent is present, then R5 is C1-4 alkoxy, halogen, C1-4 alkyl or hydroxy, if two R5 substituents are present, these are identical and are attached to the same carbon atom, and are they select from halogen or C1-4 alkyl or, together with the carbon atom to which they are attached, form a spiro-linked cyclopropanic ring, R6 is -NH-C (O) -R7, -C (O) -NR8R9, halogen, hydroxy or NH2, R61 is halogen, C1-4 alkyl or hydroxy.Compuesto de fórmula (I)**Fórmula** en la que R1 es -CH2-cicloalquilo de C3-6 o alquilo de C1-4 opcionalmente sustituido con R11, R11 es alcoxi de C1-4 o hidroxi, R2 es hidrógeno o alquilo de C1-4 R21 es hidrógeno o fluoro, R22 es hidrógeno, halógeno, alquilo de C1-4, alcoxi de C1-4, hidroxi, fluoroalcoxi de C1-
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