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תכשיר רפואי למתן דרך הפה
专利权人:
ASTELLAS PHARMA INC.
发明人:
申请号:
IL23742315
公开号:
IL237423D0
申请日:
2015.02.25
申请国别(地区):
IL
年份:
2015
代理人:
摘要:
In order to provide the medical field with a single formulation comprising a modified release portion containing mirabegron or a pharmaceutically acceptable salt thereof and an immediate release portion containing solifenacin or a pharmaceutically acceptable salt thereof, (1) a single formulation having dissolution rates of both drugs similar to those of the current single drug formulations is provided, and (2) a single formulation having maximum percentages of dissolution of both drugs of 90% or more, and having a bioavailability equivalent to those of the current single drug formulations. Further, in order to provide a single formulation, (3) a single formulation having good productivity whereby failures in tabletting are reduced, and having good storage stability whereby the coloration of the immediate release portion is suppressed is provided. The pharmaceutical composition for oral administration of the present invention contains (1) a modified release portion comprising mirabegron or a pharmaceutically acceptable salt thereof, and (2) an immediate release portion comprising solifenacin or a pharmaceutically acceptable salt thereof, and calcium stearate.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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