In various embodiments, a surgical cassette, configured to engage peristalticpumprollers, may include two or more pump segments between a sheet and a substratecoupled tothe sheet. The two or more pump segments on the cassette may produceadditional flow(e.g., approximately twice the flow for two segments as opposed to one) thanif the cassettehad only one pump segment engaging the roller. Further, in some embodiments,the two ormore pump segments and rollers on the roller head may be configured to providea flowprofile in which a peak of a pulse from a first pump segment is at leastpartially out of phasewith a peak of a pulse from the second pump segment. The combined resultantflow maythen have a flow profile with pulsation amplitudes that are smaller than theindividual pumpsegment pulsation amplitudes.
