Iain Robert Greig;Robert Jurgen Van't Hof;Stuart Hamilton Ralston
发明人:
Iain Robert Greig,Robert Jurgen Van't Hof,Stuart Hamilton Ralston,Robert Jurgen Vant Hof
申请号：
US12531732
公开号：
US08524778B2
申请日:
2008.03.20
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl sulfonamides and related compounds (collectively referred to herein as ‘BPSAAA compounds’), as described herein, and including, for example, biphenyl-4-sulfonic acid (hydroxyalkyl-phenyl)-amides and related compounds. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment and/or prevention, for example, of inflammation and/or joint destruction and/or bone loss； of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system； of, inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like； of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activation in rheumatoid arthritis, osteoporosis, cancer associated bone disease, Paget's disease and the like.
