АЛКИЛ[2-(2-{5-[4-(4-{2-[1-(2-МЕТОКСИКАРБОНИЛАМИНО-АЦЕТИЛ)-ПИРРОЛИДИН-2-ИЛ]-3Н-ИМИДАЗОЛ-4-ИЛ}-ФЕНИЛ)-БУТА-1,3-ДИИНИЛ]-1Н-ИМИДАЗОЛ-2-ИЛ}-ПИРРОЛИДИН-1-ИЛ)-2-ОКСО-ЭТИЛ]-КАРБАМАТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЛЕКАРСТВЕННОЕ СРЕДСТВО, СПОСОБ ЛЕЧЕНИЯ ВИРУСНЫХ ЗАБОЛЕВАНИЙ
The present invention relates to NS5A inhibitors, to a novel pharmaceutical composition, to an antiviral medicinal agent, and to a method for the prevention and treatment of viral diseases, particularly those caused by the hepatitis C (HCV) and hepatitis GBV-C viruses. Proposed are alkyl [2-(2-{5-[4-(4-{2-[1-(2-methoxycarbonylamino-acetyl)-pyrrolidine-2-yl]-3H-imidazole-4-yl}-phenyl)-buta-1,3-dienyl]-1H-imidazole-2-yl}-pyrrolidine-1-yl)-2-oxo-ethyl]carbamate of general formula 1 and their naphthalene-1,5-disulfonates of general formula 1.1, where: R1, R2, R3 and R4 independently of one another are C1-C3 alkyl R5 and R6 independently of one another are C1-C3 alkyloxymethyl, or R3 and R5 and R4 and R6 along with the carbon atoms with which they are linked, form, independently of one another, a tetrahydrofuran cycle, where: R1, R2, R3 and R4 independently of one another are C1-C3 alkyl R5 and R6 independently of one another are C1-C3 alkyl or C1-C3 alkyloxymethyl, or R3 and R5 and R4 and R6, along with the carbon atoms with which they are linked, form, independently of one another, a tetrahydrofuran cycle.La présente invention concerne des inhibiteurs NS5A, une nouvelle composition pharmaceutique, un médicament antiviral, un procédé de prévention et de traitement de maladies virales, notamment de celles provoquées par les virus de lhépatite virale C(HCV) et de lhépatite virale GBV-C on a proposé un alkyl [2-(2-{5-[4-(4-{2-[1-(2-méthoxycarbonylamino-acétyl)-pyrrolidin-2-yl]-3n-imidazol-4-yl}-phényl)-buta-1,3-diinyl]-1n-imidazol-2-yl}-pyrrolidin-1-yl)-2-oxo-éthyl]-carbamate correspondant à la formule générale 1 et ses naphtalin-1,5-disulphonate mate correspondant à la formule générale 1.1, dans lesquelles : R1, R2, R3 et R4 sont indépendamment C1-C3 alkyle R5 и R6 sont indépendamment C1-C3 alkyloxyméthyle, ou R3 и R5 и R4 и R6 avec les atomes de carbone auxquels ils sont liés forment indépendamment les uns des autres un cycle tétrahydrofurane, dans lequel : R1, R2, R3 и
