PROCEDIMENTO DE CRISTALIZAÇÃO PARA OBTENÇÃO DE CRISTAIS DE CANAGLIFLOZINA HEMI-HIDRATADA

• 收藏
• 分享

专利权人:

JANSSEN PHARMACEUTICA N.V.

发明人:

申请号：

PT16819899

公开号：

PT3394051T

申请日:

2016.12.20

申请国别(地区):

PT

年份:

2020

代理人:

摘要：

The present invention relates to an improved crystallization procedure to obtain canagliflozin hemihydrate crystals having a narrow particle size distribution by removing a small part of the crystalline suspension in the crystallization vessel from said vessel and subjecting said part to particle size reduction of the formed crystals followed by heating and reintroducting said part of the crystalline suspension again in the crystallization vessel which is kept within a specific temperature range.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/