DE KEYSER, Ruben,LAPS, Stijn,RAMMELOO, Thomas Joachim Landewald,WEERTS, Koen Johan Herman
申请号：
LT16819899
公开号：
LT3394051T
申请日:
2016.12.20
申请国别(地区):
LT
年份:
2020
代理人:
摘要：
The present invention relates to an improved crystallization procedure to obtain canagliflozin hemihydrate crystals having a narrow particle size distribution by removing a small part of the crystalline suspension in the crystallization vessel from said vessel and subjecting said part to particle size reduction of the formed crystals followed by heating and reintroducting said part of the crystalline suspension again in the crystallization vessel which is kept within a specific temperature range.
