MIGAUD, Marie Eugenie,REDPATH, Philip,CROSSEY, Kerri,CUNNINGHAM, Richard,RHONEMUS, Troy,VENKATARAMAN, Sylesh
申请号：
EP20160804531
公开号：
EP3302059(A1)
申请日:
2016.06.03
申请国别(地区):
欧洲专利局
年份:
2018
代理人:
摘要：
A synthetic process is provided for the preparation of phosphorylated analogs of nicotinamide riboside ("NR") having the formula (I), or salts thereof, and reduced or modified derivatives thereof, having the formula (II), wherein X-, Y1, Y2, Z1, Z2, n, R1, R2, R3, R4, R5, R6, and R7 are as defined herein. The present disclosure also relates to the preparation of phosphorylated analogs of nicotinic acid riboside ("NAR") having the formula (I), or salts thereof, and reduced or modified derivatives thereof, having the formula (II). Generally solvent-free conditions are employed using appropriate mechano-chemical techniques as described. (I) (II)
