THE QUEEN'S UNIVERSITY OF BELFAST;CHROMADEX, INC.; INC.;CHROMADEX
发明人:
MIGAUD, MARIE EUGENIE,REDPATH, PHILIP,CROSSEY, KERRI,CUNNINGHAM, RICHARD,RHONEMUS, TROY,VENKATARAMAN, SYLESH
申请号：
CA2987986
公开号：
CA2987986A1
申请日:
2016.06.03
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
A synthetic process is provided for the preparation of phosphorylated analogs of nicotinamide riboside ("NR") having the formula (I), or salts thereof, and reduced or modified derivatives thereof, having the formula (II), wherein X-, Y1, Y2, Z1, Z2, n, R1, R2, R3, R4, R5, R6, and R7 are as defined herein. The present disclosure also relates to the preparation of phosphorylated analogs of nicotinic acid riboside ("NAR") having the formula (I), or salts thereof, and reduced or modified derivatives thereof, having the formula (II). Generally solvent-free conditions are employed using appropriate mechano-chemical techniques as described. (I) (II)
