The present invention relates to a skin-whitening and skin-protection composition that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained fromDendrobiumplants, such asDendrobiumofficinaleandDendrobiumnobilefor the management of melanogenesis, skin-darkening and skin-aging. More particularly, it relates to the usage ofDendrobiumingredients and stilbenoids to reduce the formation of melanin in melanocytes. It also relates to the usage ofDendrobiumingredients and stilbenoids to reduce the generation of reactive oxygen species and oxidative free radicals. This invention relates to the use ofDendrobium-derived extracts or ingredients or stilbenoids in the formulation of skin-protection, skin-whitening and/or anti-skin aging products. Compounds for use in preparation of a composition for treating, preventing, and/or delaying the progress of skin darkening or for use in skin-whitening and skin-protection which are synthesized from dihydro-resveratrol and the related synthesis method are also provided in the present invention.本發明是涉及皮膚美白及皮膚保護的組合物，其包含自石斛屬植物(如鐵皮石斛及金釵石斛等)中獲得之芪類及/或含芪類的提取物，並在管理黑色素生成、皮膚變黑及皮膚老化中的應用。更具體而言，本發明涉及石斛屬成分及芪類用於減少黑色素細胞中黑色素形成之用途。本發明亦涉及石斛屬成分及芪類用於減少活性氧物種及氧化自由基產生之用途。本發明亦涉及石斛屬衍生之提取物或成分或芪類用於調配皮膚保護、皮膚美白及/或抗皮膚老化產品之用途。本發明亦提供用於製備供治療、預防及/或延遲皮膚變黑進展或用於皮膚美白及皮膚保護之組合物的化合物，該等化合物是自二氫-白藜蘆醇合成。本發明亦提供相關的合成方法。
