DNATRIX, INC.;BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
发明人:
FUEYO, JUAN,MANZANO-GOMEZ, CANDELERIA,CONRAD, CHARLES,LANG, FRED,YUNG, W.K. ALFRED,TUFARO, FRANK
申请号：
CA2915973
公开号：
CA2915973A1
申请日:
2014.06.13
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present disclosure involves compositions and methods for treating brain cancers having mutations in the retinoblastoma (Rb) pathway using an oncolytic adenovirus comprising an alteration in the Rb binding site of El A, and a targeting motif inserted in the Ad fiber protein. The adenovirus is able to kill the tumor cells without harming cells with a wild-type retinoblastoma pathway.
