DNATRIX, INC.;BOARD OF REGENT, THE UNIVERSITY OF TEXAS SYSTEM
发明人:
Juan FUEYO-MARGARETO,Candelaria MANZANO-GOMEZ,Charles CONRAD,Fred LANG,W.K. Alfred YUNG,Frank TUFARO
申请号：
US14899360
公开号：
US20160143967A1
申请日:
2014.06.13
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure involves compositions and methods for treating brain cancers having mutations in the retinoblastoma (Rb) pathway using an oncolytic adenovirus comprising an alteration in the Rb binding site of E1A, and a targeting motif inserted in the Ad fiber protein. The adenovirus is able to kill the tumor cells without harming cells with a wild-type retinoblastoma pathway.
